While I do not know the balance factor it uses, the smoothest bike I have ever owned is my Ducati 750 GT. Rather mildly tuned at 60 hp, 8.5:1 compression, with bore and stroke of 80 x 74.4. It is a pleasure to ride at any speed and I could literally balance a quarter on the tank while it was idling on its center stand. My wife and I rode it from Maine to the Ohio North American Vincent rally and back in the 80's, and while the thing was a bit cramped for us and gear, I had no problem with hands or feet from vibrations. After it was taken off the road for a never completed rebuild, I bought a '75 860 GT. While it only increased the bore and kept the same stroke ( 86 x 74.4), and I believe it used the same frame geometry, it was quite a bit more buzzy, did not feel the same, and I sold it not much later. Sometimes a perfect combination of factors gives a great result, which for me was a nice touring machine. Slight changes can affect that combination of factors. I also owned an ST4 a few years ago, and did not like the way it vibrated, as it would put my fingers to sleep. (and try to change the battery!). My Vincent never bothered me, and while it vibrated a bit, it was of another lower order, and was about the same before and after I pushed the flywheels together myself after the drive side mainshaft got loose, and I'm sure I did a poor job of aligning them with my lead hammer. The original spec Rapide seems to be pretty forgiving.
Ron