G'day Mike,
You will need something in the vicinity of 12 to 13:1 compression ratio to make good use of methanol. Although ratios far in excess of 15:1 have been used. Because of the large main jets that have to be used you will need large bore fuel taps and fuel lines and fittings. Because you have a lot of fuel going out of the tank, don't forget to have a large breather to get replacement air in. All dependent on engine condition, you are going to need main jets around the 1200 mark. Amal GPs' are made for Methanol, others will have to be modified by generally opening out the float needle and seat.